Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery
نویسندگان
چکیده
منابع مشابه
An approach to Improve Therapeutic Efficacy of Doxycycline Hyclate in Treatment of Periodontitis
A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...
متن کاملAn approach to Improve Therapeutic Efficacy of Doxycycline Hyclate in Treatment of Periodontitis
A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...
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In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components was established. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The formulation...
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This study proposed a drug delivery system based on a series of formulations with chitosan gels, designed for local, intra-pocket treatment of periodontal disease, containing two drugs (an antibiotic and a chimiotherapeutic-antimicrobian agent: tetracycline hydrochloride (T) and metronidazole benzoate (M), respectively. The formulations varied from the chitosan concentration (3-4%), and the dru...
متن کاملFormulation optimization and characterization of spray dried microparticles for inhalation delivery of doxycycline hyclate.
The local delivery of antibiotics in the treatment of infectious respiratory diseases is an attractive alternative to deliver high concentration of antimicrobials directly to the lungs and minimize systemic side effects. In this study, inhalable microparticles containing doxycycline hyclate, sodium carboxymethylcellulose, leucine and lactose were prepared by spray drying of aqueous ethanol form...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2021
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2021.01.009